Just moved my server to FC12 x86_64 from FC10 i686 and now SSL doesn't appear to be working with s3sync:
/usr/lib/ruby/1.8/net/http.rb:586:in `connect': certificate verify failed (OpenSSL::SSL::SSLError)
   from /usr/lib/ruby/1.8/net/http.rb:586:in `connect'
   from /usr/lib/ruby/1.8/net/http.rb:553:in `do_start'
   from /usr/lib/ruby/1.8/net/http.rb:548:in `start'
   from ./S3_s3sync_mod.rb:55:in `make_http'
   from ./s3try.rb:62:in `S3tryConnect'
   from ./s3try.rb:71:in `S3try'
   from s3sync.rb:285:in `s3TreeRecurse'
   from s3sync.rb:346:in `main'
   from ./thread_generator.rb:79:in `call'
   from ./thread_generator.rb:79:in `initialize'
   from ./thread_generator.rb:76:in `new'
   from ./thread_generator.rb:76:in `initialize'
   from s3sync.rb:267:in `new'
   from s3sync.rb:267:in `main'
   from s3sync.rb:735

My setup is very close to:
http://paulstamatiou.com/how-to-bulletproof-server-backups-with-amazon-s3

I'm using the Fedora version of ruby, but can't seem to get SSL to work correctly.  Any thoughts?